ORIGINAL ARTICLE

 

Primary stability of orthodontic miniscrews inserted into femurs of osteopenic rats

 

 

Rogério Lacerda dos Santos^I; Matheus Melo Pithon^I; Mônica Tirre de Souza Araújo^II; Matilde Gonçalves da Cunha Nojima^II; Lincoln Issamu Nojima^II

^ISpecialist in Orthodontics, Federal University of Alfenas, Alfenas, MG, Brazil; Master in Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; PhD student in Orthodontics; Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
^IIAdjunct Professor of Orthodontics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Correspondence to

 

 

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ABSTRACT

AIM: To test the hypothesis that bone quality may affect the stability of anchorage devices implanted in a rat model.
METHODS: Twenty male Wistar rats were divided into 2 groups: Group 1 (rats treated with FK506) and Group 2(rats treated with saline solution vehicle). The immunosuppressant tacrolimus was used with the intention of causing a condition of osteopenia in Group 1. A total of 20 orthodontic mini-implants were used. One mini-implant was inserted in the right femur of each rat. After sacrificing the animals, blocks of bone tissue containing the mini-implants were removed for mechanical pull-out tests to be performed in a universal test machine at a crosshead speed of 0.5 mm/s. The maximum insertion force values and pull-out test were recorded and submitted the nonparametric analyses including the Kruskal-Wallis test and Mann-Whitney tests (p<0.05). The test for Pearson's correlation was used to verify the correlation between bone mineral density and the pull-out test. The dose of FK506 was 2 mg/kg/day. Densitometric analysis was performed to observe the effect of FK506 on the bone mineral density.
RESULTS: The mean insertion force values were similar in both groups, with no statistically significant difference between them (P > 0.05). The mean pull-out force values were higher in Group 2 than in Group 1, with statistically significant difference between the groups (P < 0.05).
CONCLUSIONS: Bone quality may affect the stability of mini-implants. Orthodontic mini-implants did not present good primary stability in a rat model with osteopenia.

Keywords: immunosuppressant, bone, miniscrew, pull-out test.

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Acknowledgements

We would like to thank the Rio de Janeiro State Research Support Foundation (FAPERJ) for supporting the research.

 

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Correspondence to:
Lincoln Issamu Nojima
Universidade Federal do Rio de Janeiro - UFRJ
Faculdade de Odontologia - Programa de
Pós-Graduação em Odontologia (Ortodontia)
Av. Professor Rodolpho Paulo Rocco, 325
CEP: 21941-617 - Ilha do Fundão
Rio de Janeiro - RJ - Brasil
E-mail: lacerdaorto@hotmail.com

Received for publication: July 15, 2010
Accepted: September 17, 2010