SOUZA, Eduardo Quintão Manhanini et al. Effects of Simvastatin as supporting in the treatment of periodontal disease induced in rats. Rev. Bras. Odontol. []. 2016, 73, 1, pp. 20-23. ISSN 1984-3747.

The study evaluated simvastatin in the treatment of periodontal disease (PD) in rats. 36 animals were divided into control group (C) receiving oral saline and Simvastatin (S) who received oral simvastatin. After 24 hours the PD was induced using a cotton yarn in the dento-gingival area of the first left molar. After 7 days the ligature was removed and animals received scaling and root planing (SRP) and irrigation with saline. The animals were sacrificed at 7, 15 and 30 days. Radiographically treatment with SRP showed less bone loss (BL) in the S group compared to C in all periods. It was concluded that SRP associated with simvastatin was effective in reducing the BL in rats.a

: Simvastatin; periodontitis; rats..