PALMA, Luiz Felipe et al. Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study. Rev. Bras. Odontol. []. 2017, 74, 2, pp. 82-87. ISSN 1984-3747.

Objective: to carry out histomorphometric analysis of the combination of rifamycin SV sodium salt with synthetic hydroxyapatite on bone repair in rabbit tibiae. Material and Methods: twelve male white rabbits were equally divided into a test group and a control group. Drill hole defects were created in the tibiae of the animals and were filled with either synthetic hydroxyapatite and physiological solution (control group) or a combination of synthetic hydroxyapatite and rifamycin (test group). Moreover, all defects were covered by expanded polytetrafluoroethylene barriers. The animals were euthanized at on day 7, 14, or 21. The tissue sections were mounted onto slides (HeE staining) and were analysed using an optical microscope. Results: the tested association presented better microbiological local control, faster bone matrix deposition rate, and higher final total amount of bone matrix deposition. Conclusion: the combination of rifamycin with synthetic hydroxyapatite seems to be advantageous under the tested conditions, encouraging the development of new animal model studies.

: Bone tissue; Hydroxyapatite; Antibacterials..