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RPG. Revista de Pós-Graduação

Print version ISSN 0104-5695

Abstract

MARTINS, Gabriela Botelho; RIBEIRO, Marlos Barbosa  and  REIS, Silvia Regina de Almeida. Analysis myofibroblasts in the stroma of squamous cell carcinoma of mouth. RPG, Rev. pós-grad. [online]. 2011, vol.18, n.4, pp. 244-252. ISSN 0104-5695.

The tumor stroma undergoes changes during the progression of malignant neoplasia. Changes in the extracellular matrix and the presence of myofibroblasts appear to influence the processes of invasion and metastasis of malignant tumors that characterize the oral. The objective was to investigate the presence of myofibroblasts in front of invasion in squamous cell carcinoma of mouth, through transmission electron microscopy and immunohistochemical markers. In this study, 23 cases of squamous cell carcinoma of the mouth from various locations were classified according to a histological grading system. Were used by hematoxylin-eosin (HE) staining and immunohistochemical expression of vimentin, the alpha smooth muscle actin and desmin were analyzed in lesions with different histological scores of malignancy. The transmission electron microscopy was used to confirm the presence of cell-type myofibroblasts in tumor stroma. The expression of vimentin showed different patterns of squamous cell carcinoma of the oral cavity with high and low scores of malignancy. The alpha-smooth muscle actin was present in some cases. Although the alpha smooth muscle actin has suggested the presence of myofibroblasts in the stroma of squamous cell carcinoma of the oral cavity, ultrastructural analysis did not confirm this result.

Keywords : Carcinoma; Microscopy, electron; Myofibroblasts.

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