Resumo

MILANI, BASÍLIO DE ALMEIDA et al. Clinical evaluation of the efficacy of amoxicillin administered in multiple doses in postoperative of lower third molar extraction. RPG, Rev. pós-grad. [online]. 2012, vol.19, n.2, pp. 69-75. ISSN 0104-5695.

The use of antibiotics to reduce postoperative infection in third molar surgery remains controversial. The goal of this study was to evaluate the efficacy of multi-dose amoxicilin in patients undergoing lower third molar extraction. The study was a prospective, randomized, double-blind, placebo-controlled trial with 32 patients. Each patient acted as their own control using the split-mouth technique. One lower third molar was removed under antibiotic cover postoperative (500 mg amoxicillin 8 hourly for 7 days) and the other was removed without antibiotic cover postoperative (placebo capsules 8 hourly for 7 days), but both surgeries it was administered preoperatively single dose of 1 g of amoxicillin. The following parameters were evaluated on the preoperative and fourth, seventh days postoperative: trismus, facial swelling, body temperature. There was no statistically significant difference in the parameters evaluated between patients operated (p > 0.05). Results of the study showed that administration of amoxicillin single dose preoperative and postoperative multiple doses was not more effective than single dose administration only pre-operative with respect to clinical parameters evaluated in the lower third molar extractions.

Palavras-chave : Amoxicillin; Antibiotic Prophylaxis; Molar, Third.