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SOUSA, Rayanne Izabel Maciel de et al. Erosive and cariogenic potential of pediatric anti-histaminic medicines. RFO UPF [online]. 2010, vol.15, n.3, pp. 255-260. ISSN 1413-4012.

OBJECTIVE: To evaluate in vitro the endogenous pH, titratable acidity, total soluble solids content (TSSC) and total sugars of pediatric anti-histaminic medicines presented as syrups. METHODS: Five medicines were evaluated by a random experiment with 3 repetitions for each sample. pH analysis was performed by potentiometry and buffering capacity was assessed by dilution of each medicine. Increments of 0.1 N KOH were titrated until neutrality was reached. TSSC readings were performed by Brix refractometry using the Abbé refractometer. RESULTS: pH values ranged from 3.33 (loratadina) to 6.84 (agasten) and four medicines showed pH below the critical value of 5.5. The titratable acidity values ranged from 0.30 (dexametasona) to 2.41 (maleato de desclofeniramina). Dexametasona presented the lowest TSSC content (13.25%) and maleato de dexclorfeniramina presented the highest TSSC content (63.66%). Regarding to total sugars values ranged from 24.80% (loratadina) to 49.34% (maleato de dexclorfeniramina). CONCLUSION: The anti-histaminic medicines evaluated have a high erosive and cariogenic potential, as they present low pH and a high total soluble solids content.

Palavras-chave : Oral administration; Pharmaceutical preparations; Sweetening agents; Dental caries; Tooth erosion.

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