Resumo

OLIVEIRA, Taiane Coutinho de et al. Fiber-enriched calcium phosphate cement implanted in the femur of rats: a histological evaluation. RFO UPF [online]. 2014, vol.19, n.1, pp. 32-36. ISSN 1413-4012.

Objective: to perform a histological analysis of nylon, carbon, and polypropylene fiber-enriched calcium phosphate cement (CPC) for use as bone substitute in the femur or rats. Materials and method: Fiber-enriched CPC blocks (6-mm diameter, 2-mm thickness) were implanted in the femur of 20 male Wistar rats. The animals were euthanized at 30, 60, 90, and 120 days, with removal and histological assessment of specimens. Results: Biocompatibility, resorption, and osteoconduction were assessed. At all times, histological assessment revealed the formation of dense connective tissue with low cellularity, little vascularization, and a few mononuclear cells. Surrounding the implant, slight resorption and hyalinization of peripheral collagen fibers were observed, with evidence of incorporation of implant material into connective tissue. Osteoid tissue was observed at 120 days. Bone resorption surrounding the implant was not significant. Conclusion: Based on the present criteria, CPC seems adequate for use as bone substitute.

Palavras-chave : Biomaterials.; Bone substitutes.; Calcium Phosphate Cements..