PAGNONCELLI, Rogério Miranda et al. Human growth hormone and the future perspective in Dentistry. RFO UPF []. 2014, 19, 3, pp. 379-383. ISSN 1413-4012.

Objective: this study aims to demonstrate, based on a literature review, the possibilities of using GH in treatments and procedures in the field of health sciences, and perspectives in Dentistry. Literature review: bone reconstructions are common in oral and maxillofacial surgery routines, indicated in facial trauma, pathology, orthognathic surgery, and Implantology. Osteoinductive biomaterials present benefits in the performance of bone grafts due to lower morbidity, wide availability and quantity of materials, and greater patient acceptance. Growth factors may emerge as an interesting alternative in the reconstruction of tissues, highlighting the growth hormone (GH), a regulator of bone growth and remodeling, which plays a key role affecting chondrocytes, osteoclasts, and osteoblasts. It also acts as a growth factor, locally produced and secreted by several cell types. Literature showed the use of GH related to bone fractures repairing, dental implants, guided bone regeneration, Mulibrey nanism treatment, bone grafts with biomaterials, wound repair, socket preservation, and in Temporomandibular Joint. Final considerations: biomaterials are present in several bone reconstructions in Dentistry. Bone substitutes from different origins are extensively used in surgical practice. The GH seems to be, in the near future, an important contributor to the evolution of this concept. Thus, research and testing of association with other biomaterials with osteoconductive features are of great interest in Dentistry.

: Growth hormone.; Bone remodeling.; Growth factor.; Maxillofacial surgery.; Biomaterials..