SciELO - Scientific Electronic Library Online

 
vol.21 issue3 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

RFO UPF

Print version ISSN 1413-4012

Abstract

MORELLO SARTORI, Letícia Regina et al. Therapies for joint disc regeneration. RFO UPF [online]. 2016, vol.21, n.3, pp. 407-413. ISSN 1413-4012.

Objective: the present study reviewed the scientific literature searching for perspectives and main challenges faced by joint disc regeneration therapies. Literature review: temporomandibular dysfunction (TMD) is a multifactorial etiology disorder in which pathologies, deformities, and malposition of the temporomandibular joint (TMJ) are present in up to 70% of diagnosed cases. Thus, applying knowledge and principles of tissue engineering for the development of therapies that seek joint disc regeneration may be an option for future treatment. Mesenchymal stem cells (MSC) are often employed with the ability to differentiate into chondrocytes and deposit tissue similar to that of TMJ. Studies have pointed out that these cells may present better regeneration than cells removed from the injured TMJ itself, which presents lower deposition of extracellular matrix. Approaches to reconstruction have used mainly synthetic scaffolds such as polymers and hydrogels, as well as natural scaffolds of collagen origin. These materials have enabled cellular proliferation and deposition of extracellular matrix. Techniques of decellularization with several organic solvents have shown the ability of not developing immune response, allowing its use. The use of growth factors seems to contribute significantly to cell signaling and differentiation, increasing the deposition of cartilaginous tissue. Final considerations: although tissue joint disc regeneration presents itself as a potential treatment option for the different types of TMD, the literature is still in an early stage of investigation with predominantly in vitro and in vivo studies.

Keywords : Tissue engineering; Regeneration; Temporomandibular Joint Disorders.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese