Resumo

FREIRES, Irlan de Almeida; ALVES, Lívia Araújo  e  CASTRO, Ricardo Dias de. Pharmacogenomics and dental practice: clinical implications and current researches. Odontol. Clín.-Cient. (Online) [online]. 2012, vol.11, n.2, pp. 97-101. ISSN 1677-3888.

Variations in the response to dental treatments may be due to several factors, including genetic variability. Pharmacogenomics is the application of genomics technology to the development of specific drugs and its relationship with dentistry is a recent area of research. This paper aims to discuss the relationship between pharmacogenomics and dental practice, focusing on clinical implications and current researches. It was used technique of documentation based on literature available at Scielo (Scientific Electronic Library Online) and MEDLINE between 2000 and 2010. Diseases and disorders can be associated with misspellings or genetic mutations. The knowledge of how genetic variation interferes in the response to treatment will allow the development of drugs to be used, for instance, in oral and systemic infection therapy; for the management of oral lesions (e.g. herpes, squamous cell carcinoma), bone resorption (e.g. periodontal diseases); chronic oral and facial pain; for the management of autoimmune and temporomandibular joint disorders. Periodontics, Cariology, Oral Pathology, among other areas, represent a vast field of research yet to be explored. In summary, dentistry begins to show an increasingly close relationship with pharmacogenomics, which may result in the development and improvement of treatment modalities more individualized and potentially more effective.

Palavras-chave : Pharmacogenomics; Dentistry; Phamarcology; Genetic polymorphism.