Resumo

KOBAYASHI, Wander Célio; DANIEL COUTO, Uchôa  e  FORTES, Ricardo Padilha. Histomorphologic analysis of bone repair in implants with growth hormone application. Odontol. Clín.-Cient. (Online) [online]. 2012, vol.11, n.2, pp. 133-138. ISSN 1677-3888.

The objective of this study was to evaluate, through histomorphological analysis, if the topical use of the recombinant Growth Hormone (rhGH) improves the bone repair around osseointegrated implants in rabbits tibias. Eight rabbits received four implant each, in their tibias. Thirty-two Biomet 3i® implants were placed, measuring 3.25mm in diameter x 8.5mm in length. The implants were placed with the aid of a torque gauge, by applying a torque force of 20 Ncm. They were divided in four groups: A (control - 28 days): eight implants without topical application of rhGH and reopening for histomorphological assessment at 28 days; A1 (test - 28 days): eight implants with topical application of rhGH and reopening for histomorphological assessment at 28 days; B (control - 56 days): eight implants without topical application of rhGH and reopened for histomorphological assessment at 56 days; B1 (test - 56 days): eight implants with topical application of rhGH and reopened for histomorphological assessment at 56 days. After 28 and 56 days, the rabbits were sacrificed and their tibias were immediately sectioned. The sheets were prepared and histomorphologically evaluated. The histological results showed that the topical use of the rhGH improved the bone repair around the implants of groups A1 and B1.

Palavras-chave : Human Growth Hormone; Osseointegration; Dental Implants.