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Revista de Cirurgia e Traumatologia Buco-maxilo-facial

versão On-line ISSN 1808-5210

Resumo

MELLO, Manoel de Jesus Rodrigues; LEITE, José Alberto Dias; VASCONCELLOS, Ricardo José de Holanda  e  MORAIS, Hécio Henrique Araújo de. Anti-inflammatory, healing and antimicrobial properties of a 20% aqueous extract of aroeira-do-sertão (myracrodruon urundeuva fr.all.) applied to induced exposed fractures in rabbit jaws. Rev. cir. traumatol. buco-maxilo-fac. [online]. 2013, vol.13, n.1, pp. 97-104. ISSN 1808-5210.

The aroeira-do-sertão (Myracrodruon urundeuva Fr.All), a tree of the Anacardiceae family, is known for its popular use as an anti-inflammatory agent, owing to its healing properties, representing a good therapeutic option. To investigate these properties we analyzed an experimental model, using induced exposed fractures in rabbit jaws. Thirty white New Zealand male rabbits weighing between 1,700 and 2,100 g, divided into two groups of fifteen animals each were used. The rabbits underwent a surgical procedure under general anesthesia to fracture their right mandibular body, which remained exposed to the oral cavity for 4 hours. Material from the fracture site was collected for microbiological analysis. The animals were randomly distributed according to the treatment proposed. In Group I, 300 ml of 20% aqueous extract of Myracrodruon urundeuva was used for the irrigation of the focus of the fracture for 5 minutes. In Group II, the same volume of 0.9% saline solution was used as in Group I. All animals underwent fracture reduction with internal rigid fixation using 1.5 mm titanium mini-plates. Before euthanasia, postoperative radiographs were taken at 7, 14, and 30 days in order to analyze the healing of the fractures, after which the bone fragment from the region operated on was removed for histological analysis using the Masson Tricromic method. The animals were analyzed from the clinical, radiological and histological perspectives. In the clinical analysis the appearance of the surgical would was examined. Group I (Myracrodruon urundeuva) showed little improvement in healing when compared to Group II. Radiographically, Group II presented no significant effects on bone healing. Histologically, a decrease in bacterial concentration in the fracture was seen in Group I. It was concluded that a 20% Myracrodruon urundeuva aqueous extract has no significant effect on the healing of induced exposed fractures of rabbit jaws, but shows benefits in wound healing, significantly reducing the colonies of bacteria at the fracture site.

Palavras-chave : Fracture Fixation; Phytotherapy; Rabbits.

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