SOBRAL, Ana Paula Veras; ALMEIDA, Híttalo Carlos Rodrigues de    FONTES, Jéssica Pereira de Sá. Correlation of Human Papillomavirus with Oral squamous cell carcinoma: Systematic Review. Rev. cir. traumatol. buco-maxilo-fac. []. 2014, 14, 2, pp. 95-102. ISSN 1808-5210.

Objective: To determine through a systematic review of the literature the correlation between the Human Papillomavirus (HPV) and oral squamous cell carcinoma . Method: Active search in the databases LILACS, MEDLINE , PubMed and SciELO using the descriptors : "Oral squamous cell carcinoma" and " Human Papillomavirus " between January 2000 until February 2014 in Portuguese, English and Spanish . Results: In the studies reviewed, the most prevalent type of HPV is low risk (6 e 54) and high risk (16), being found in lesions on the tongue and floor of mouth in male patients , age over 60 years and nonsmokers. Conclusions: Studies are needed that allow consider HPV as the causative agent of oral squamous cell carcinoma, because in the literature the presence of several carcinogens , acting concurrently , prevents accurate conclusions and point to a synergistic action between HPV and other carcinogens that actually potentiate developing a malignancy.

: Human Papillomavirus; Oral squamous cell carcinoma; Polymerase Chain Reaction..