Abstract

PEREIRA-SANTOS, Darklilson  and  BREDA JUNIOR, Marcus Antônio. Effects of co-administered dexamethasone and nimesulid on pain, swelling and trismus following third molar surgery. Rev. cir. traumatol. buco-maxilo-fac. [online]. 2015, vol.15, n.4, pp. 65-66. ISSN 1808-5210.

This study aimed to compare the effect of the co-administration of dexamethasone 8 mg and nimesulide 100 mg 1 hour before symetricallypositioned third molarsremoval. A prospective, randomized, doubleblind, split-mouth type clinical trial was developed involving 40 patients. The patients were carefully allocated and divided into 2 groups: Group 1 (dexamethasone and placebo) and group 2 (dexamethasone and nimesulide). Each patient underwent two surgical procedures on different occasions under local anesthesia. The following parameters were evaluated: pain (VAS), total number of rescue analgesics used, time taken to first rescue analgesics consumption, edema, trismus, and patient satisfaction. Statistically significant differences were found in pain variables at 2, 4, 12 hours, total number of rescue analgesics and time required for first rescue analgesic consumption (p <0.05), with the highest values occurring during dexamethasone and nimesulide administration. Edema and trismus presented lower values during the administration of the two treatments. Dexamethasone does not reduce pain when administered alone, but acts in edema and postoperative trismus reduction. The co-administration of dexamethasone and nimesulide reduces pain, edema and trismus in third molar removal surgeries.

Keywords : third molar; pain; edema; trismus; anti- Inflammatory agents.