Resumo

FARIA, Márcio Antonio et al. Histological analysis of surgically injured rabbit mandibles treated topically with strontium chloride. RGO, Rev. gaúch. odontol. (Online) [online]. 2010, vol.58, n.4, pp. 487-490. ISSN 1981-8637.

OBJECTIVE: This study histologically assessed the effect of applying strontium chloride topically to surgically-induced bone defects in rabbit mandibles. METHODS: Small holes were made surgically on both sides of the lateral region of the mandible of 12 New Zealand rabbits. The holes on the right side were then filled with a collagen sponge soaked in saline (control) and the holes on the left were filled with a collagen sponge soaked in a 2 molar solution of strontium chloride. The animals were divided into two groups: the control group or GI was killed 28 days later and the experimental group or GII was killed 56 days later. The material was included for routine histological processing and the slices were stained with hematoxylin and eosin (HE). RESULTS: At 28 days, the topical application of strontium chloride had stimulated and accelerated new bone formation in the surgically-induced bone defects. At this time, the newly formed bone was mostly primary. At 56 days, newly formed bone had completely filled both the holes treated with saline and strontium chloride. However, the newly formed bone in the holes treated with strontium chloride was more developed, presenting several Haversian systems. CONCLUSION: Topical application of strontium chloride stimulates and accelerates the repair of surgically-induced bone defects in rabbit mandibles.

Palavras-chave : Rabbits; Strontium; Mandible; Bone regeneration.