Resumo

OLIVEIRA, Eder Magno Ferreira de et al. Use of recombinant proteins for maxillary reconstruction. RGO, Rev. gaúch. odontol. (Online) [online]. 2011, vol.59, n.3, pp. 491-496. ISSN 1981-8637.

Jaw bone reconstruction after tumour resection, traumatic avulsion or even atrophy due to disuse is one of the most challenging clinical tasks for implantologists and maxillofacial surgeons. Autogenous bone, with its osteogenic, osteoinductive and non-antigenic properties, has been considered the gold standard in the resolution of bone availability problems. However, the need for a second surgical site in order to harvest the bone graft significantly increases both the cost and the morbidity related to reconstructive procedures. Bone grafting gained an important tool with the discovery of bone morphogenetic proteins (BMPs) in the 1960s. Obtaining a true, functional bone matrix without bone harvesting may be the greatest benefit from BMP usage. Nevertheless, fundamental aspects of BMP application such as the control of protein release throughout the process of bone repair are yet to be fully understood, with clinical guidelines for usage of the protein remaining uncertain. Moreover, long-term clinical studies assessing the biomechanical properties of bone formed after BMP application are sporadic. Although promising, the widespread use of bone morphogenetic proteins by implantologists and maxillofacial surgeons demands greater scientific support.

Palavras-chave : Tissue engineering.; Recombinant proteins.; Bone transplantation..