WEYLL, Bárbara Mayoral Pedroso; OLIVEIRA, Thaís Feitosa Leitão de; CARNEIRO JUNIOR, Bráulio    RAMALHO, Luciana Maria Pedreira. Oral leukoplakia: malignant transformation after four years of surgical excision. RGO, Rev. gaúch. odontol. (Online) []. 2012, 60, 3, pp. 385-389. ISSN 1981-8637.

Leukoplakia is the most prevalent precancerous lesion of the oral cavity, and given it is malignant potential, patients must periodically be followed up. The aim of this article was to report a clinical case a woman patient, alcohol abuser and smoker for over 25 years, who is an oral leukoplakia carrier. Histopathological examination indicated the presence of a moderate epithelial dysplasia while immunohistochemistry for Ki-67 and cyclin D1 revealed the presence of cellular proliferation in suprabasal layers. Therefore, the removal of the lesion with surgical laser was the elected treatment. Since then, the patient has been followed up for 3 years, however, after two sequential follow up absences, she returned with recurrence of the lesion, with a history of eight months progression. Histopathological examination revealed the presence of a well differentiated carcinoma.

: Carcinoma.; Leukoplakia oral.; Surgery oral..