Resumo

JARDELINO, Cristina et al. Biocompatibility analysis of a novel reabsorbable alloplastic membrane composed of alginate-Capsul. RGO, Rev. gaúch. odontol. (Online) [online]. 2012, vol.60, n.4, pp. 419-423. ISSN 1981-8637.

Objective The aim of this study was to evaluate in vivo the biological response after implantation of a novel alginate-capsule membrane. Methods The material was implanted into subcutaneous tissue of mice (n=15) and after 1, 3 and 9 weeks, the animals were sacrificed and biopsies analyzed with light microscopy, using the stains hematoxylin-eosin, picrosirius and alcian blue pH 2.5. The parameters evaluated were: intensity and kind of inflammatory infiltrate, presence of connective tissue, foreign body reaction, vascularization and biodegradation. Results 1 week after implantation, the following was observed: mixed inflammatory infiltrate, absence of necrosis and beginnings of membrane fragmentation; after 3 weeks, discrete presence of multinuclear giant cells and beginnings of neovascularization; and after 9 weeks there was minor biodegradation associated with the presence of new connective tissue, and persistence of moderate inflammatory reaction observed from beginning to end of the experiment. Conclusion Considering the results obtained, it is possible to conclude that the novel alginate-capsule membrane is partially reabsorbable but with low biocompatibility, requiring more tests to validate its clinical use.

Palavras-chave : Material testing; Seaweed; Tissue engineering.