Resumo

DOS SANTOS JUNIOR, Valdeci Elias et al. Mechanism of action of chlorhexidine on metalloproteinase enzymes and their clinical impact: a review study. RFO UPF [online]. 2016, vol.21, n.3, pp.306-311. ISSN 1413-4012.

Objective: to analyze the mechanism of action of chlorhexidine on the matrix metalloproteinases (MMPs) enzymes and their clinical impact. Materials and method: the search strategy included Medline, Lilacs, and Pubmed databases. The articles were selected based on the following criteria: be written in English, Spanish, or Portuguese, be formatted as an original article, have abstracts available, address issues that relate MMPs to adhesive systems and/or the influence of chlorhexidine on these enzymes, and be published between 2005 and 2015. Results: 34 articles were found, but only 18 studies were included after the critical analysis of abstracts. Final considerations: the use of chlorhexidine as a therapeutic primer after acid etching prevents activating the metalloproteinase enzyme that degrades the collagen network, causing failure in adhesive restorations. Therefore, the use of this substance must be encouraged to avoid adhesive failure in restorations, increasing their lifetime.

Palavras-chave : Chlorhexidine; Collagen; Dentin; Restoration.

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