Abstract

SOARES, Álvaro Cavalheiro; ALENCAR, Felipe Souza Lima  and  ANTUNES, Héliton Spindola. Oral manifestations of chronic graft vs host disease: systematic literature review. Rev. Bras. Odontol. [online]. 2016, vol.73, n.2, pp. 157-164. ISSN 1984-3747.

Objective: To identify the frequency of oral manifestations of cGVHD in patients undergoing HSCT, through a systematic review of the literature. Material and Methods: It was performed a systematic review of the literature using the databases PubMed, Cochrane and Dentistry & Oral Sciences Source to perform the literature search (september/ 2015), which resulted in a total of 212 publications, among which 40 were included in the study. Results: The lichenoid lesions were reported in 82.5% of the studies, the most frequent changes among many others found, such as ulcers, reported in 57,1% of the studies, mucosal atrophy in 45,7%, mucocele in 37,1% pseudomembranes in 17.1%. Among the symptoms, dry mouth was reported in 80% of studies, overcoming the pain (48,5%), sensitivity/burning (34,2%) dysgeusia/ageusia (17,1%), dysphagia (14,2%), among others. Conclusion: There was, in the literature, a high occurrence of various oral manifestations associated with cGVHD.

Keywords : stem cell transplantation; graft vs host disease; lichenoid eruptions; ulcer; xerostomia..