Abstract

ALENCAR, Felipe Souza Lima; SOARES, Álvaro Cavalheiro  and  ANTUNES, Héliton Spindola. Treatment of oral manifestations of chronic graft versus host disease: systematic literature review. Rev. Bras. Odontol. [online]. 2016, vol.73, n.2, pp. 156-172. ISSN 1984-3747.

Objective: To summarize the main therapeutic modalities used in the treatment of oral manifestations of graft versus host disease (GVHD), through a systematic review of the literature. Material and Methods: A search was conducted in the databases Cochrane Library, Dentistry & Oral Sciences and Pubmed, with descriptors for the treatment of chronic GVHD with oral involvement, between June and October 2015. The methodology was defined from reading the titles, abstracts and articles available. Results: Founded 32 publications that presented a total of 13 immunosuppressant drugs, and 07 which were employed by local therapy and systemically 06. Two articles treated auxiliary therapies to relieve hyposalivation. Conclusion: Drugs found may serve as parameters for future drugs to be used in clinical practice. The treatment of oral GVHD still has limited effectiveness, however, suggests the use of topical medications to reduce systemic effects. Prospective studies are needed, randomized controlled trials to prove the effectiveness of these medications.

Keywords : therapy; graft-versus-host disease; immunosuppressants; steroids; oral manifestations..