Abstract

PASQUALI, Carlos Eduardo Zanella et al. rhBMP-2 applicability in different grafting techniques. RFO UPF [online]. 2014, vol.19, n.3, pp. 384-389. ISSN 1413-4012.

Objective: to examine the influence of rhBMP-2 in bucco- facial grafts, presenting recent research on animals and humans, as well as different approaches to clinical application and the results obtained by the authors. Literature Review: to allow either the installation of implants or the correction of bone defects, high quality bone tissue is required. Otherwise, the chances of success in osseointegration procedures and bucco-facial rehabilitation that aim to provide the patient with the bone volume lost are greatly reduced. Bone morphogenetic proteins (BMPs) are osteoinductive substances and have been used in bone regeneration. The search for materials presenting characteristics similar to those achieved with autograft, aiming to reduce morbidity in procedures of restoration of lost bone structures, allowed research to develop toward synthetic materials, such as the rhBMP-2, which is the main morphogenetic protein inducer of bone tissue. Final Considerations: further studies are needed to analyze the feasibility and success of the application of these proteins. Hence, it may be observed that these proteins play an important role in bone formation.

Keywords : Bone Morphogenetic Proteins.; Bone Regeneration.; Osseointegration.; TGF-beta Superfamily Proteins..