Abstract

ROSSI, Ana Cláudia; FREIRE, Alexandre Rodrigues  and  DORNELLES, Rita Cássia Menegati. Osteoporosis: considerations on the recent therapies and bone metabolism. IJD, Int. j. dent. [online]. 2010, vol.9, n.4, pp. 210-214. ISSN 1806-146X.

The process of bone remodeling is regulated by systemic and local factors. Estrogen is an important hormone for maintaining normal bone remodeling, whose deficiency leads to changes in bone turnover with resorption exceeding formation, as observed in postmenopausal women. Treatment for osteoporosis is related to drug discovery alternative to hormone therapy estrogen offset the disadvantages of this therapy. The aims of this review were report the effect of the osteoporosis on the alveolar bone and demonstrate the efficacy of the therapies currently used for treatment of this disease, emphasizing studies on the Selective Estrogen Receptor Modulators and the sodium fluoride. The review was divided into 3 topics: (1) Bone metabolism, (2) Effects of the osteoporosis on the alveola bone, (3) Therapies used for treatment of the osteoporosis. Raloxifene (RLX) mimics the beneficial effects of estrogen without stimulating tissues such as breast and endometrium. The sodium fluoride (NaF) presents itself as an agent effective against fractures resulting from osteoporosis.

Keywords : Osteoporosis; Bone metabolism; Raloxifene; Sodium fluoride.