Abstract

NOIA, Cláudio Ferreira et al. Biocompatibility evaluation of a system for internal fixation based on a resorbable polymer: a histological study in rabbits. Rev. cir. traumatol. buco-maxilo-fac. [online]. 2010, vol.10, n.3, pp. 059-066. ISSN 1808-5210.

Some undesirable characteristics of metal fixation materials prompted researchers to develop a system for resorbable internal fixation, thus requiring studies to evaluate their behavior, particularly with regard to their biocompatibility. The aim of this study was to make a comparative histological evaluation of the reaction of bone tissue to a local internal fixation system based on resorbable poly (L-co-D, L-lactic acid) 70:30, using an internal fixation system with the same dimensions based on a titanium alloy (Ti-6Al-4V/Grau V) as a control. For this purpose we selected 15 female albino New Zealand rabbits, aged approximately 6 months and weighing between 3.8 and 4.5 kg at the time of surgery. Each animal received both the absorbable and metallic systems, with the animals being randomly sacrificed postoperatively at 3, 8 and 16 weeks. No exacerbated reaction of this tissue was observed at the time of sacrifice in either group. We thus conclude that the fixation system based on resorbable material displayed a satisfactory biocompatibility with the recipient bed.

Keywords : Fixation systems; resorbable polymers; histological study.