Abstract

PEREZ, Mariana de Moraes Corrêa et al. Analysis of the polymorphism of osteoprotegerin by polymerase chain reaction in patients with type 2 diabetes and the association with periodontal condition. RGO, Rev. gaúch. odontol. (Online) [online]. 2013, vol.61, n.1, pp. 99-105. ISSN 1981-8637.

Objective The aim of this paper was to analyze the presence of polymorphism in the promoter region T/C950 of the osteoprotegerin gene and its distribution in diabetic patients with periodontitis, when compared to the control group. Methods 67 patients took part in the research. The test group (n = 32) was composed of diabetic patients with periodontitis and the control group (n = 35) included patients without diabetes and without periodontitis. For the diagnosis of periodontitis, the following clinical parameters were evaluated: probing depth, bleeding on probing and clinical attachment level. The DNA to investigate the polymorphisms of osteoprotegerin, obtained through the technique of polymerase chain reaction, was obtained from the blood serum of the participants. Results Polymorphisms of osteoprotegerin were found in promoter region -950T/C but there was no significance (p=1.000). Only the control group showed significant results for the probing depth according to the polymorphic region. Conclusion No influence was found between genetic polymorphisms of osteoprotegerin in patients with diabetes and periodontitis.

Keywords : Diabetes mellitus; Genetic polymorphism; Osteoprotegerin; Periodontitis.