Abstract

PEREIRA, Claudio Maranhão; MELO, Laura Guimarães; GASPARETTO, Patrícia Freire  and  CORREA, Maria Elvira P.. Chronic graft versus host disease: a scleroderma-like case report. RSBO (Online) [online]. 2011, vol.8, n.2, pp. 236-239. ISSN 1984-5685.

INTRODUCTION: Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. Oral manifestations are diagnosed in approximately 80% of patients with chronic GVHD. OBJECTIVE: To present a case of chronic GVHD with scleroderma-like lesions in skin and oral cavity CASE REPORT: A 27-year-old female was admitted, in a Hematology Center, in 1997, with previous diagnosis of chronic myeloid leukemia since 1994. Over past four months after allogeneic BTM she developed cGVHD in eyes, mouth, liver, lungs and skin. The patient presented sclerotic skin changes, hyperkeratosis of hands and xerophthalmia. CONCLUSION: Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous.

Keywords : bone marrow transplantation; graft-versus-host disease; oral cavity.